Groeihormonenreceptor (hGH-bindingseiwit), oplosbaar

The somatotropin receptor (GHR) is the protein in the cell membrane of vertebrates to which the hormone somatropin (somatotropin, STH, GH), a growth factor, binds. The receptor belongs to the cytokine receptors. Its main actions are activation of a JAK-STAT signaling pathway, expression of insulin-like growth factor 1, and binding to the tyrosine kinase-coupled receptors SHP-2, which cause overall and length growth and fat loss in the body during the growth phase. Mutations in the GHR gene can lead to somatropin resistance and this can lead to a form of short stature called Laron syndrome. GHR in humans is produced primarily in liver and skeletal muscle. Three of the four GHR isoforms are transmembrane receptors, and the soluble isoform is called somatropin-binding protein (GHBP) . It lacks the cytoplasmic domain, and by reversible binding to somatropin, it functions as a buffer for this hormone in blood plasma.

GH receptor, Somatotropin receptor, Growth hormone-binding protein (GH-binding protein; GHBP), Serum-binding protein

2690

P10912

NP_000154.1

NM_000163.5

Human

Human

AFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFY

It is recommended to reconstitute the lyophilized hGHBP in sterile 0.4% NaHCO3 adjusted to pH 8 or in distilled water, not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

< 0.1 ng/µg of protein (< 1EU/µg)

> 95.0% as determined by Gel filtration and SDS-PAGE gel.

RhGHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with hGH.

247

Lyophilized

Water

28.4 kDa

E. coli

AFSGS