GRPR Antilichaam

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.

2925

P30550

P30550

Human

This GRPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-152 amino acids from the Central region of human GRPR.

Unconjugated

Primary Antibodies

Neuroscience, Signal Transduction, Growth Factors

This antibody is purified through a protein A column, followed by peptide affinity purification.

Batch dependent

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

43 kDa

Rabbit Ig

GRPR

Gastrin-releasing peptide receptor

Homo sapiens

Guey, L.T., et al. Eur. Urol. 57 (2) :283-292 (2010)

Chapuis, J., et al. Mol. Psychiatry 14 (11) :1004-1016 (2009)

Chao, C., et al. J. Surg. Res. 156 (1) :26-31 (2009)

Ananias, H.J., et al. Prostate 69 (10) :1101-1108 (2009)

Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR

WB, IHC-P, Flow

232185

Liquid