GSAP Antibody - N-terminal regio: Biotine (ARP48798_P050-Biotine)

Pigeon homolog (Drosophila)

PION

54103

A4D1B5

NP_059135

Human, Rat, Cow, Dog, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N-terminal region of Human GSAP

Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease. Formation of amyloid-beta is catalyzed by gamma-secretase, a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein C-terminal fragment (APP-CTF) .

Biotin

Polyclonal Antibody

WB

Affinity purified

0.5 mg/ml

Cow: 85%; Dog: 85%; Horse: 93%; Human: 100%; Rabbit: 93%; Rat: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

93kDa

Wet Ice

854

GSAP

GSAP

Rabbit

Gamma-secretase-activating protein

QTRQNELLYTFEKDLQVFSCSVNSERTLLAASLVQSTKEGKRNELQPGSK