GSDMA Antilichaam / Gasdermin A

Gasdermin-A is a protein that plays a crucial role in programmed cell death, or pyroptosis, a process that is essential for the body to eliminate infected or damaged cells. This protein acts as a pore-forming molecule, causing the cell membrane to rupture and release pro-inflammatory molecules that signal the immune system to clear away the debris. Recent studies have shown that dysregulation of Gasdermin-A can lead to a variety of health issues, including autoimmune diseases, inflammatory disorders, and even cancer.

Western blot: 1:500-1:1000, Immunohistochemistry (FFPE) : 1:50-1:100, Flow cytometry: 1:10-1:50 per million cells in 0.1ml

Q96QA5

Human, Mouse

A portion of amino acids 66-94 from the human protein was used as the immunogen for this GSDMA antibody.

WB, IHC-P, FACS

Antigen affinity

Antigen affinity purified

This GSDMA antibody is available for research use only.

Store at 4°C for up to one month. For long term, aliquot the GSDMA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

The stated application concentrations are suggested starting amounts. Titration of the GSDMA antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Cytoplasm, cell membrane

IHC staining of FFPE human skin tissue with GSDMA antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.