GSK2606414
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Potent (IC50 = 0.4 nM) and selective (against a panel of 294 kinases) inhibitor of protein kinase R-like endoplasmic reticulum kinase (PERK), an important effector of the unfolded protein response (UPR) .1 It prevented neurodegeneration in a mouse model of frontotemporal dementia2 and rodent models of Parkinsons disease via modulation of the UPR3. GSK2606414 has been reported to be a potent inhibitor of RIPK1 (IC50 = 18 nM) .4 It has also displayed neuroprotective effects in various models of stroke.5-7
Unconjugated
Off-white solid
-20°C
Beschrijving
GSK2606414 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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