GSK2830371
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Potent allosteric inhibitor of WIP1 phosphatase (IC50 = 6 nM), a negative regulator of the DNA damage response.1 It displayed no inhibition of 21 other phosphatases. Active in xenograft model DoHH2 B-cell lymphoma. GSK2830371 in combination with MDM2 inhibitors has been shown to be efficacious in the treatment of various cancers including liver adenocarcinoma2, acute myeloid leukemia3, and breast4. It enhances phosphorylation of the tumor suppressor p53 leading to activation.5,6
Unconjugated
Tan solid
-20°C
Beschrijving
GSK2830371 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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1 set
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1 Kit
OSR1 (Oxidative Stress Responsive 1)
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0.1 mL
Oxidative Stress Combo Assay Cell Kit
EA-7006
1 Each
Oxidative Stress Combo Assay Blood Kit
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1 Each
Oxidative Stress Combo Assay Tissue Kit
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1 Each
OSR1 (Oxidative Stress Responsive 1)
O8054
100 µL