GSK3β-IN-3
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
GSK3β-IN-3 is an ATP-competitive GSK-3β inhibitor (IC50 = 0.90 μM) . GSK3β-IN-3 can reduce the phosphorylation level of tau protein in the BR5706 strain and reduce the deposition of Aβ aggregates in the CL2006 strain, and can be used to research Alzheimer's disease (AD) [1].
301359-45-5
12352005
H302-H315-H319-H335
Amyloid-β; Cytochrome P450; GSK-3; Tau Protein
Metabolic Enzyme/Protease; Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Neuroscience-Neurodegeneration
Neurological Disease
CCOC(C1=C(NC(NC1C2=CC=CC=C2Cl)=S)C)=O
C14H15ClN2O2S
310.80
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
[1]Sukanya S, et al. Exploring 2-Thioxo-1,2,3,4-tetrahydropyrimidines as Dual Acting GSK-3β/Aβ Aggregation Inhibitors: Implications for Alzheimer's Disease Treatment. Drug Dev Res. 2025 Jun;86 (4) :e70112.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W098905/
Reference compound2
No Development Reported
GSK-3β
Beschrijving
GSK3β-IN-3 is an ATP-competitive GSK-3β inhibitor (IC50 = 0.90 μM) . GSK3β-IN-3 can reduce the phosphorylation level of tau protein in the BR5706 strain and red
Specificaties
Recent bekeken producten
ExactaCruz® Pipette Tip Reload System, 50-1250 μl, case
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Denhardt's Solution (50X)
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FKBP4, ID (FK506-binding Protein 4, Peptidyl-prolyl cis-trans Isomerase FKBP4, PPIase FKBP4, Rotamase, HSP-binding Immunophilin, HBI, FKBP52 Protein, 52kD FK506-binding Protein, 52kD FKBP, FKBP-52, 59kD Immunophilin, FKBP59, p59 Protein, FKBP-4, FKBP52)
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Human Sertoli Cell Complete Medium
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100 mL
Urobilinogen protein
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100 mg
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48 Well