GSK3alfa Antilichaam [6G12C2]

Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily, GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

2931

P49840

P49840

Human

Ni-NTA purified truncated recombinant GSK3 alpha expressed in E. Coli strain BL21 (DE3) .

6G12C2

Unconjugated

Primary Antibodies

Signal Transduction

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

GSK3 alpha monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

GSK3A

Glycogen synthase kinase 3 alpha

Homo sapiens

Mendez P, Garcia-Segura LM. Endocrinology. 2006 Jun;147 (6) :3027-39. Epub 2006 Feb 23.

Bianchi M, De Lucchini S, et, al. Biochem J. 2005 Oct 15;391 (Pt 2) :359-70.

De Servi B, Hermani A, Medunjanin S, Mayer D. Oncogene. 2005 Jul 21;24 (31) :4946-55.

GSK-3 alpha

ELISA, WB

12644292