GSK3alfa Antilichaam [6G2F1 / 6G2F2]

GSK3 alpha (Glycogen synthase kinase 3 alpha), with 483-amino acid protein (about 53 kDa), belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily, GSK3 subsubfamily, which also includes GSK3 beta.GSK3 is a multifunctional serine/threonine kinase that is usually inactivated by serine phosphorylation in response to extracellular cues. GSK3 is a key regulator of numerous signalling pathways, including cellular responses to Wnt, receptor tyrosine kinases and G-protein-coupled receptors and is involved in a wide range of cellular processes, ranging from glycogen metabolism to cell cycle regulation and proliferation.GSK3 alpha is implicated in the control of several regulatory proteins including glycogen synthase and transcription factors.

2931

P49840

P49840

Human

Ni-NTA purified truncated recombinant GSK3 alpha expressed in E. Coli strain BL21 (DE3) .

6G2F1 / 6G2F2

Unconjugated

Primary Antibodies

Signal Transduction

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

GSK3 alpha monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

GSK3A

Glycogen synthase kinase 3 alpha

Homo sapiens

Bradley W. Doble and James R. Woodgett. J. Cell Sci., Apr 2003; 116: 1175.

C. Laura Sayas , Aafke Ariaens, Bas Ponsioen. Mol. Biol. Cell, Apr 2006; 17: 1834 – 1844.

GSK-3 alpha

ELISA, WB, IHC

12644292