GSK3beta (Ab 216) Antilichaam

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

2932

P49841

NP_001139628.1

Human, Mouse, Rat

GSK3beta (Ab-216) antibody was raised against a peptide sequence around aa.214~218 (V-S-Y-I-C) derived from Human GSK3b (GSK3-beta) .

Unconjugated

Primary Antibodies

Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

46 kDa

This antibody detects endogenous level of total GSK3β protein.

Western Blot: 1:500~1:1000

GSK3B

Glycogen synthase kinase 3 beta

Homo sapiens

Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13; 137 (1-2) : 193-201Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02; 316 (2) : 411-415Fan G, et al. J Biol Chem 2003 Dec 26; 278 (52) : 52432-52436Liao X, et al. Mol Cancer Ther 2003 Nov; 2 (11) : 1215-1222

Factor A, GSK-3 beta, Protein kinase GSK-3-beta, kinase GSK-3 beta

WB

225903437

Liquid