GSK3beta (Ab 9) Antilichaam

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

2932

P49841

NP_001139628.1

Human, Mouse, Rat

GSK3beta (Ab-9) antibody was raised against a peptide sequence around aa.7~11 (T-T-S-F-A) derived from Human GSK3β .

Unconjugated

Primary Antibodies

Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

46 kDa

This antibody detects endogenous level of total GSK3β protein, this antibodymay cross-react with the GSK-3α due to high sequence homology.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

GSK3B

Glycogen synthase kinase 3 beta

Homo sapiens

Fan G, et al. (2003) J Biol Chem. 278 (52) : 52432-52436. Barry FA, et al. (2003) FEBS Lett. 553 (1-2) : 173-178. Welsh, et al. (1996) Trends Cell Biol. 6: 274-279. Srivastava A K, et al. (1998) Mol Cell Biochem. 182: 135-141. Cross D. A, et al. (1995) Nature. 378: 785-789.

VIL2

WB, IHC, IF

225903437

Liquid