GSTA4 (NM 001512) Humaan recombinant eiwit

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]

Purified recombinant protein of Human glutathione S-transferase alpha 4 (GSTA4), full length, with C-terminal DDK tag, expressed in CHO cells.

GSTA4-4; GTA4

2941

O15217, A0A024RD58

NM_001512

6p12.2

CHO

C-DDK

Drug metabolism - cytochrome P450, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450

Drug metabolism - cytochrome P450, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450

>50 ug/mL as determined by microplate BCA method

> 90% as determined by SDS-PAGE and Coomassie blue staining

Liquid

PBS, pH7.4, 10% glycerol

29.3 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

GSTA4

Human

NP_001503

https://www.ncbi.nlm.nih.gov/gene/2941

https://www.uniprot.org/uniprot/O15217

https://www.ncbi.nlm.nih.gov/nuccore/NM_001512

https://www.ncbi.nlm.nih.gov/nuccore/NP_001503