Guanine-13C2,7-15N

Guanine-13C2,15N is the 13C- and 15N-labeled Guanine. Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects[1][2][3][4].

1207525-05-0

12352005

DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Cancer-programmed cell death

Cancer

O=C1NC(N)=N[13C]2=[13C]1[15N]=CN2

C3 13C2H5N4 15NO

154.10

[1]Mojzeš P, et al. Guanine, a high-capacity and rapid-turnover nitrogen reserve in microalgal cells. Proc Natl Acad Sci U S A. 2020 Dec 22;117 (51) :32722-32730. |[2]Chauhan V, et al. In Silico Discovery and Validation of Amide Based Small Molecule Targeting the Enzymatic Site of Shiga Toxin. J Med Chem. 2016 Dec 8;59 (23) :10763-10773. |[3]Messina E, et al. Guanine nucleotide depletion triggers cell cycle arrest and apoptosis in human neuroblastoma cell lines. Int J Cancer. 2004 Mar 1;108 (6) :812-7.|[4]de Oliveira ED, et al. Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice. Eur J Pharmacol. 2016 Feb 5;772:71-82.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W778114/

Reference compound2

No Development Reported