GUB021794

GUB021794 is a potent and highly selective glucagon-like peptide-1 receptor (GLP-1R) agonist developed using the streaMLine platform with an EC50 value of 18 pM. GUB021794 has a very weak activity against SCTR, with an EC50 value of 190 nM. GUB021794 can significantly reduce the body weight, food intake, and total fat mass of mice in a diet-induced obesity (DIO) model. GUB021794 can be used for research on obesity/diabetes[1].

12352209

GLP Receptor

GPCR/G Protein

Metabolic Disease

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C178H282N40O55

3862.38

[1]Nielsen JC, et al. Machine-Learning-Guided Peptide Drug Discovery: Development of GLP-1 Receptor Agonists with Improved Drug Properties. J Med Chem. 2024 Jul 25;67 (14) :11814-11826.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11262/

Peptides

No Development Reported