GW-1100 (standaard)

GW-1100 (Standard) is the analytical standard of GW-1100. This product is intended for research and analytical applications. GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9.

306974-70-9

12352100

Free Fatty Acid Receptor; Reference Standards

GPCR/G Protein; Others

Metabolic Disease

O=C1C(CC2=CN=C(N=C2)OCC)=CN(C(SCC3=CC=C(C=C3)F)=N1)C4=CC=C(C(OCC)=O)C=C4

C27H25FN4O4S

520.58

[1]Stoddart LA, et al. Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O- (3-[35S]thio) triphosphate binding studies reflects binding of an endogenous agonist. Mol Pharmacol. 2007 Apr;71 (|[2]Briscoe CP, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148 (5) :619-28.|[3]Manosalva C, et al. Cloning, identification and functional characterization of bovine free fatty acid receptor-1 (FFAR1/GPR40) in neutrophils. PLoS One. 2015 Mar 19;10 (3) :e0119715.|[4]Nakamoto K, et al. Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatorychronic pain. PLoS One. 2013 Dec 12;8 (12) :e81563.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-50691R/

Reference Standards