H-FABP Antilichaam / Harttype vetzuurbindingseiwit / FABP3

The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants.

Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 2-4 µg/mL

P05413

Human

A human partial recombinant protein (from within amino acids 1-127 was used as the immunogen for the H-FABP antibody.

FABP3/3770

IHC-P, WB

Protein G affinity

Purified

This H-FABP antibody is available for research use only.

Aliquot the H-FABP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

1 mg/mL in 1X PBS; BSA free, sodium azide free

Optimal dilution of the H-FABP antibody should be determined by the researcher.

Cytoplasm

IHC staining of FFPE human heart tissue with PSAP antibody (clone FABP3/3770) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.