H2AX (Ubiquityl Lys119) Polyklonale Antilichaam, AbBy FluorTM 350 Vervoeging

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

H2AX; H2A.X; H2A/X; Histone H2AX; Histone H2A.X; H2AFX

3014

P16104

Nucleus

Human, Rat

H2AX (Ubiquityl Lys119)

AbBy Fluor™ 350

KLH conjugated synthetic peptide derived from human Ubiquityl Histone H2A.X (Lys119)

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

346nm/442nm

1µg/µl

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

This modification site is homologous to that of Lys119 in Rat.

3014

Cow, Pig, Rabbit