H2AX (Ubiquityl Lys119) Polyklonale Antilichaam, Biotinevervoeging

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

H2AX; H2A.X; H2A/X; Histone H2AX; Histone H2A.X; H2AFX

3014

P16104

Nucleus

Human, Rat

H2AX (Ubiquityl Lys119)

Biotin

KLH conjugated synthetic peptide derived from human Ubiquityl Histone H2A.X (Lys119)

WB, ELISA, IHC-P, IHC-F

Purified by Protein A.

1µg/µl

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C for 12 months.

This modification site is homologous to that of Lys119 in Rat.

3014

Cow, Pig, Rabbit