H4C5 (NM 003545) Humaan Recombinant eiwit

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

Purified recombinant protein of Human histone cluster 1, H4e (HIST1H4E), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

H4-16; H4/j; H4C1; H4C2; H4C3; H4C4; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4FJ; HIST1H4E

8367

P62805, B2R4R0

NM_003545

6p22.2

E. coli

N-GST and C-His

Systemic lupus erythematosus

Systemic lupus erythematosus

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

39.2 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

H4C5

Human

NP_003536

https://www.ncbi.nlm.nih.gov/gene/8367

https://www.uniprot.org/uniprot/P62805

https://www.ncbi.nlm.nih.gov/nuccore/NM_003545

https://www.ncbi.nlm.nih.gov/nuccore/NP_003536