Halometason

Halometasone is a corticosteroid compound that can reduce the expression of serum leukotriene B4 (LTB4) and thymic stromal lymphopoietin (TSLP) . Halometasone can be used in research on psoriasis and eczematous skin diseases[1].

50629-82-8

12352211

H302, H312, H332, H351

Leukotriene Receptor

GPCR/G Protein

COVID-19-immunoregulation

Inflammation/Immunology

98.47

F[C@@]12[C@](C[C@@H](C([C@@]2(C=C3Cl)C)=CC3=O)F)([H])[C@@]4([H])[C@](C[C@@H]1O)([C@](O)([C@@H](C4)C)C(CO)=O)C

C22H27ClF2O5

444.90

H302, H312, H332, H351

[1]Zhu J W, et al. Role of VEGF receptors in normal and psoriatic human keratinocytes: evidence from irradiation with different UV sources[J]. PLoS One, 2013, 8 (1) : e55463.|[2]Cao J, et al. Effect of halometasone cream combined with Simiao pill on the therapeutic effect and expression of serum leukotriene B4 (LTB4) and thymic stromal lymphopoietin (TSLP) in patients with eczema, and the factors influencing its clinical efficacy. Ann Palliat Med. 2021 Nov;10 (11) :11643-11652.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W341962/Halometasone-SDS-MedChemExpress.pdf

Reference compound1

Phase 4

LTB4