Hamarin (TSC1) (NM 000368) Humaan Recombinant eiwit

This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018]

Purified recombinant protein of Human tuberous sclerosis 1 (TSC1), transcript variant 1, Ser836-His1164, with N-terminal His tag, expressed in E. coli, 50ug

LAM; TSC

7248

Q92574, Q86WV8, X5D9D2

NM_000368

9q34.13

E. coli

N-His

Insulin signaling pathway, mTOR signaling pathway

Insulin signaling pathway, mTOR signaling pathway

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

36.6 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

TSC1

Human

NP_000359

https://www.ncbi.nlm.nih.gov/gene/7248

https://www.uniprot.org/uniprot/Q92574

https://www.ncbi.nlm.nih.gov/nuccore/NM_000368

https://www.ncbi.nlm.nih.gov/nuccore/NP_000359