HAMP Antilichaam

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.

57817

P81172

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 1-84 of human HAMP (NP_066998.1) .

Unconjugated

Primary Antibodies

Immunology, Innate Immunity, Signal Transduction

Affinity purification

MDA-MB-435

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 10kDa

IgG

WB: 1:500 - 1:2000

HAMP

Hepcidin antimicrobial peptide

Homo sapiens

Putative liver tumor regressor, liver-expressed antimicrobial peptide, PLTR, LEAP1, LEAP-1, HFE2B, HEPCIDIN, HEPC, hepcidin antimicrobial peptide, HAMP, UNQ487/PRO1003

WB

Liquid