HAX1 Antilichaam - middengebied: FITC (ARP52141_P050-FITC)

HCLS1 associated protein X-1

SCN3, HS1BP1, HCLSBP1

10456

O00165

NP_006109

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse

The immunogen is a synthetic peptide directed towards the middle region of human HAX1

HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease.The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.

ERLIN2; UBC; BIRC3; CEP250; TUBGCP2; TUBGCP3; MAPK10; HIPK1; DYRK4; ZNF420; POLR1D; ZNRD1; RBX1; STAT5B; RPA1; PPP3CC; CFTR; EWSR1; SHC1; HTRA2; NEDD4L; CUL3; CUL4A; PIDD1; SVIL; EBNA-LP; AMFR; HNF4G; AKAP10; TUBB4A; ABCC4; MATN4; EIF3D; RGS1; HSP90AB1; H

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB, IHC

Affinity Purified

HAX1 is supported by BioGPS gene expression data to be expressed in COLO205

0.5 mg/ml

Cow: 86%; Dog: 93%; Guinea Pig: 100%; Horse: 85%; Human: 100%; Mouse: 100%; Rat: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

31kDa

Lees, D.M., (2008) J. Mol. Biol. 379 (4), 645-655

Wet Ice

279

HAX1

HAX1

Rabbit

HCLS1-associated protein X-1

NM_006118

LPGPESETPGERLREGQTLRDSMLKYPDSHQPRIFGGVLESDARSESPQP