HCK (fosfo-Tyr521) Antilichaam

The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.

3055

P08631

NP_002101.2

Human, Mouse, Rat

HCK (phospho Tyr521) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 521 (E-S-Q (p) -Y-Q) derived from Human HCK .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

60 kDa

IgG

The antibody detects endogenous levels of HCK only when phosphorylated at tyrosine 521.

Western Blot: 1:500~1:1000

HCK

HCK proto-oncogene, Src family tyrosine kinase

Homo sapiens

Quintrell N., Mol. Cell. Biol. 7:2267-2275 (1987) [PubMed: 3496523].

Ziegler S.F., Mol. Cell. Biol. 7:2276-2285 (1987) [PubMed: 3453117].

Ota T., Nat. Genet. 36:40-45 (2004) [PubMed: 14702039].

P59-HCK/p60-HCK, Hemopoietic cell kinas, Tyrosine-protein kinase HCK

WB

287326139

Liquid