HDAC1 Antilichaam - C-terminaal gebied: Biotine (ARP38530_T100-Biotine)

Histone deacetylase 1

HD1, RPD3, KDAC1, GON-10, RPD3L1

3065

Q13547

NP_004955

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human HDAC1

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. HDAC1 also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

BCL6; CUL4B; YY1; SIN3A; RCOR1; KDM1A; KAT5; NCOR2; SUMO1; DDIT3; DDB1; BCOR; SF3A1; TP53; SP1; SUMO2; NFKB1; NFE2L2; MDM2; SMAD3; SMAD1; JUN; CHFR; HIF1A; HDAC2; EP300; SAP130; UBC; RELA; RB1; RARA; PRDM6; HAUS2; FEZF2; BANP; WHSC1; ESR1; DNMT3B; DNMT1

Biotin

Polyclonal Antibody

WB

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Yeast: 91%; Zebrafish: 77%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

55kDa

Hsu, M.C., et al., (2006) J. Biol. Chem. 281 (8), 4718-4725

Wet Ice

482

HDAC1

HDAC1

Rabbit

Histone deacetylase 1

NM_004964

SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKP