HDAC2 Antilichaam

The histone deacetylase (HDAC) family contains multiple members which are divided into four classes. Class I of the HDAC family comprises four members, HDAC1, 2, 3, and 8, each of which contains a deacetylase domain and exhibits a different, individual substrate specificity and function in vivo (1) . HDAC2 was first identified as as a mammalian homolog to the yeast transcriptional regulator RPD3 (2) . HDAC2 forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor (2,3) . Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events (4) .

3066

Q92769

NP_001518

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cell Cycle, Stem Cell

HDAC2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (94%)

HDAC2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

HDAC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

HDAC2 antibody is human, mouse and rat reactive. At least two isoforms of HDAC2 are known to exist; this antibody will detect both isoforms. HDAC2 antibody is predicted to not cross-react with other members of the HDAC family.

HDAC2

Histone deacetylase 2

Homo sapiens

Taunton J, Hassig CA, and Schreiber SL. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 1996; 272:408-11.

Yang WM, Inouye C, Zeng Y, et al. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc. Natl. Acad. Sci. USA 1996; 93:12845-50.

Cress WD and Seto E. Histone deacetylases, transcriptional control, and cancer. J. Cell Phys. 2000; 184:1-16.

Kramer OH. HDAC2: a critical factor in health and disease. Trends Pharmacol. Sci. 2009; 30:647-55.

HDAC2 Antibody: HD2, RPD3, YAF1, Histone deacetylase 2, HD2

ELISA, WB, IHC-P, IF

293336691

Liquid