HDAC3 Antilichaam

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation

8841

O15379

NP_003874.2

Human, Mouse, Rat

HDAC3 antibody was raised against a peptide sequence around aa.420~424 (N-D-K-E-S) derived from Human HDAC3.

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

49 kDa

This antibody detects endogenous level of total HDAC3 protein.

Western Blot: 1:500~1:1000

HDAC3

Histone deacetylase 3

Homo sapiens

HD3, RPD3, RPD3-2, HD3

WB

13128862

Liquid