HDAC4 Antilichaam - middengebied: Biotine (ARP34230 P050-Biotine)

Histone deacetylase 4

HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A

9759

P56524

NP_006028

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human HDAC4

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC4 belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UBC; TP53BP1; KRT31; MTUS2; KDM5B; HDAC5; NCOR2; PNMA1; KRT38; YWHAG; KRT40; CCDC136; RINT1; ANKRA2; EFEMP2; LDOC1; GSK3B; GOLGA2; CDR2; BCL6; YWHAQ; YWHAB; YWHAE; SIRT1; UBE2I; TBL1XR1; HDAC4; NCOR1; YWHAZ; YWHAH; SFN; MIF4GD; ZBTB7B; APP; ATF3; JDP2; Bt

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 93%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

119kDa

Lee, C.W., (2008) Mol. Pharmacol. 73 (5), 1454-1464

Wet Ice

1084

HDAC4

HDAC4

Rabbit

Histone deacetylase 4

NM_006037

YLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELL