HDAC5 Antilichaam

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

10014

Q9UQL6

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 550-650 of human HDAC5 (NP_005465.2) .

Unconjugated

Primary Antibodies

Cell Cycle, Immunology, Signal Transduction, Stem Cell

Affinity purification

SW620

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 132kDa

IgG

HDAC5

Mouse brain

Mouse heart

Rat brain

Rat heart

Histone deacetylase 5

Homo sapiens

HD5, NY-CO-9, NFKB3, HD5

WB, IHC, IF

Liquid