HDAC5 (fosfo Ser498) Antilichaam

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

10014

Q9UQL6

NP_001015053.1

Human, Mouse, Rat

HDAC5 (Phospho-Ser498) antibody was raised against a peptide sequence around phosphorylation site of serine 498 (T-Q-S (p) -S-P) derived from Human HDAC5/7.

Unconjugated

Primary Antibodies

Phospho-Specific, Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

124 kDa

This antibody detects endogenous level of HDAC5 only when phosphorylated at serine498.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

HDAC5

Histone deacetylase 5

Homo sapiens

Doppler H, et al. (2005) J Biol Chem. 280 (15) : 15013-15019. McKinsey TA, et al. (2000) Nature. 408 (6808) : 106-111.

HD5, NY-CO-9, NFKB3, HD5

WB, IHC

62750349

Liquid