HDAC6 Antilichaam

The histone deacetylase (HDAC) family contains multiple members which are divided into four classes. Class II of the HDAC family comprises six members, HDAC4, 5, 6, 7, 9 and 10, each of which appear to have tissue-specific roles (1) . HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other (2) . HDAC6 has been shown to be part of the microtubule network and acts as a specific alpha-tubulin deacetylase, and has been suggested to be a potential therapeutic target in neurodegenerative disease (3) .

10013

Q9UBN7

NP_006035

Human, Mouse

Unconjugated

Primary Antibodies

Neuroscience

HDAC6 antibody is affinity chromatography purified via peptide column.

Cat. No. 1313 - Human Testis Tissue Lysate

1 mg/mL

HDAC6 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

HDAC6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

HDAC6 antibody is human and mouse reactive. Multiple isoforms of HDAC6 are known to exist. HDAC6 antibody is predicted to not cross-react with other members of the HDAC family.

HDAC6

Cat. No. 11-701 - Human Testis Tissue Slide

Histone deacetylase 6

Homo sapiens

De Ruijter AJ, van Gennip AH, Caron HN, et al. Histone deacetylases (HDACs) : characterization of the classical HDAC family. Biochem. J. 2003; 370:737-49.

Grozinger CM, Hassig CA, and Schrieber SL. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. USA 1999; 96:4868-73.

Li G, Jiang H, Chang M, et al. HDAC6: a-tubulin decetylase: a potential therapeutic target in neurodegenerative disease. J. Neurol. Sci. 2011; 304:1-8.

HDAC6 Antibody: HD6, JM21, CPBHM, KIAA0901, Histone deacetylase 6, HD6

ELISA, WB, IHC-P, IF

13128864

Liquid