HDPTP Polyklonale Antilichaam, PE-Cy5,5 Vervoeging

HD-PTP is a 1,636 amino acid protein encoded by the human gene PTPN23. HD-PTP belongs to the protein-tyrosine phosphatase family, non-receptor class subfamily. It contains one BRO1 domain, two TPR repeats and one tyrosine-protein phosphatase domain. The C-terminal region contains the PTP-like domain, whereas the N-terminal region contains the two TPR regions. These regions are homologous to the yeast protein, BRO1, which is involved in the mitogen-activated protein kinase signaling pathway. Similarly, HD-PTP is believed to act as a negative regulator of Ras-mediated mitogenic activity and is phosphorylated upon DNA damage, probably by ATM or ATR. HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor (VEGF) has no affect on protein levels, Fibroblast Growth Factor-2 (FGF-2) induces HD-PTP degradation via the proteasome system.

DKFZP564F0923; EC 3.1.3.48; HD PTP; HD-PTP; HDPTP; His domain containing protein tyrosine phosphatase; His domain protein tyrosine phosphatase; His domain-containing protein tyrosine phosphatase; KIAA1471; Protein tyrosine phosphatase non receptor type 23; protein tyrosine phosphatase non-receptor type 23; Protein tyrosine phosphatase TD 14; protein tyrosine phosphatase TD14; PTN23_HUMAN; PTP TD14; PTP-TD14; PTPN 23; PTPN23; Tyrosine protein phosphatase non receptor type 23; Tyrosine-protein phosphatase non-receptor type 23.

25930

Cytoplasm, Nucleus

Human, Rat

1501-1636/1636

HDPTP

PE-Cy5.5

KLH conjugated synthetic peptide derived from human HDPTP

WB, FCM

Purified by Protein A.

488nm/694nm

1µg/µl

WB (1:300-5000), FCM (1:20-100)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

25930

Mouse, Pig, Chicken