Hedamycine

Hedamycin is a quinone antibiotic. Hedamycin has anti-Gram-positive bacteria, negative bacterium, mycobacterium and yeast fungus activity (MIC is 0.031-3.2 μg/mL) . 0.8 μg/mL of Hedamycin can inhibit Tetrahymena pyriformis. Hedamycin also can inhibit rat duodenum adenocarcinoma, rats Walker 256 tumor (50 μg/kg/day), HeLa cell (IG50 is 0.00013 μg/mL), e. coli lysogenic W1709 (λ) phage (MIC is 0.0125 μg/mL) [1].

11048-97-8

12352005

Antibiotic; Bacterial

Anti-infection

Infection

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C41H50N2O11

746.84

[1]Lan Chun Tu, et al. Hedamycin, a DNA alkylator, induces (gamma) H2AX and chromosome aberrations: involvement of phosphatidylinositol 3-kinase-related kinases and DNA replication fork movement. Mol Cancer Ther. 2005 Aug;4 (8) :1175-85.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N14671/

Natural Products

No Development Reported