HENT1+hUPF1 Polyklonale Antilichaam, Biotin Vervoeging

In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability (13) . Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase.

ATP dependent helicase RENT1; ATP-dependent helicase RENT1; Delta helicase; HUPF 1; HUPF1; KIAA0221; Nonsense mRNA reducing factor 1; NORF 1; NORF1; pNORF 1; pNORF1; Regulator of nonsense transcripts 1; RENT 1; RENT1; RENT1_HUMAN; Smg 2; Smg 2 homolog nonsense mediated mRNA decay factor; UP Framesht 1; Up framesht mutation 1 homolog S. cerevisiae; Up framesht mutation 1 homolog; Up framesht suppressor 1 homolog; Up-framesht mutation 1 homolog S. cerevisiae; Up-framesht suppressor 1 homolog; UPF 1; UPF 1 regulator of nonsense transcripts homolog; UPF1.

5976

Cytoplasm

Human, Mouse

301-450/1129

RENT1+hUPF1

Biotin

KLH conjugated synthetic peptide derived from human RENT1/hUPF1

ELISA, IHC-P, IHC-F

Purified by Protein A.

1µg/µl

ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C for 12 months.

5976

Rat, Dog, Cow, Horse, Chicken