HEPACAM2 Antilichaam

HEPACAM2 Antibody: HEPACAM2 (Hepatocyte cell adhesion molecule 2), a type I N-linked transmembrane glycoprotein, belongs to the immunoglobulin superfamily. The exact function of HEPACAM2 is currently unknown, but the related protein HEPACAM forms cishomodimers on the cell surface to regulate the cell adhesion and may inhibit cell growth through suppression of cell proliferation. HEPACAM and HEPACAM2 mRNA are differentially regulated in canine tumors, with HEPACAM2 mRNA showing increased levels in adenomas, but decreased levels in metastatic carcinomas compared to normal tissues, while HEPACAM protein levels decreased in adenomas. It is therefore likely that HEPACAM2 plays a different role than HEPACAM in the development and progression to tumors.

253012

A8MVW5

NP_001034461

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

HEPACAM2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1403 - Mouse Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (95%)

HEPACAM2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

HEPACAM2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

51 kDa

IgG

HEPACAM2 antibody is human, mouse and rat reactive. At least two isoforms of HEPACAM2 are known to exist; this antibody will detect both isoforms. HEPACAM2 antibody is predicted to not cross-react with HEPACAM.

HEPACAM2

HEPACAM family member 2

Homo sapiens

Klopfleisch R, Klose P, da Costa A, et al. HEPACAM1 and 2 are differentially regulated in canine mammary adenomas and carcinomas and its lymph nodes metastases. BMC Veterinary Res. 2010; 6:15.

Moh MC, Tian Q, Zhang T, et al. The immunoglobulin-like cell adhesion molecule HEPACAM modulate cell adhesion and motility through direct interaction with the actin cytoskeleton. J. Cell Physiol. 2009; 219:382-91.

Lee LH, Moh MC, Zhang T, et al. The immunoglobulin-like cell adhesion molecule HEPACAM induces differentiation of human glioblastoma U373-MG cells. J. Cell Biochem. 2009; 107:1129-38.

HEPACAM2 Antibody: MIKI, MIKI, UNQ305/PRO346, HEPACAM family member 2, Mitotic kinetics regulator

ELISA, WB

86439957

Liquid