Heparan Sulfate Proteoglycan 2 (HSPG2) (NM 005529) Humaan Recombinant eiwit

This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

Purified recombinant protein of Human heparan sulfate proteoglycan 2 (HSPG2), Leu4131-End, with N-terminal His tag, expressed in E. coli, 50ug

HSPG; PLC; PRCAN; SJA; SJS; SJS1

3339

P98160

NM_005529

1p36.12

E. coli

N-His

ECM-receptor interaction

ECM-receptor interaction

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Druggable Genome

27.7 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

HSPG2

Human

NP_005520

https://www.ncbi.nlm.nih.gov/gene/3339

https://www.uniprot.org/uniprot/P98160

https://www.ncbi.nlm.nih.gov/nuccore/NM_005529

https://www.ncbi.nlm.nih.gov/nuccore/NP_005520