Heparanase/HPSE, Human (CHO, zijn)

Heparanase (HPSE) functions as an endoglycosidase, playing a crucial role in the cleavage of heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. It is implicated in various cellular processes, including facilitating cell migration associated with metastasis, wound healing, and inflammation. Heparanase also plays a role in cell adhesion to the ECM, independent of its enzymatic activity, and induces AKT1/PKB phosphorylation, thereby increasing cell mobility and invasion. Additionally, Heparanase is involved in the regulation of osteogenesis, promotes angiogenesis through up-regulation of SRC-mediated activation of VEGF, and is implicated in hair follicle inner root sheath differentiation and hair homeostasis. Heparanase/HPSE Protein, Human (CHO, His) is the recombinant human-derived Heparanase/HPSE protein, expressed by CHO , with N-6*His labeled tag.

Heparanase/HPSE Protein, Human (CHO, His), Human, CHO

12352202

95.0

10855 (Gene_ID) AAD41342.1 (Q36-I543) (Accession)

Approximately 78 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Room temperature in continental US; may vary elsewhere.

Stored at -20°C for 2 years

Recombinant Proteins