Heptahistidine

Hepta-histidine is an inhibitor of Ku70-Huntingtin protein interaction. Hepta-histidine can reverse the morphological abnormalities of primary neurons differentiatied from hiPSCs. Hepta-histidine prolongs the lifespan in severe Huntington’s disease R6/2 mouse model. Hepta-histidine ameliorates DNA damage in vitro. Hepta-histidine can be used to study anti-aggregation agent against Tau-associated neurodegenerative diseases such as Alzheimer’s disease and Huntington’s disease[1][2].

64134-31-2

12352005

Huntingtin

Neuronal Signaling

Neurological Disease

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C42H51N21O8

978.01

[1]Kondo K, et al., Hepta-Histidine Inhibits Tau Aggregation. ACS Chem Neurosci. 2021 Aug 18;12 (16) :3015-3027.|[2]Imamura T, et al., Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Sci Rep. 2016 Sep 22;6:33861.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-180346/

Reference compound

No Development Reported