HER2 (fosfo-Tyr1248) Antilichaam

Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.

2064

P04626

NP_001005862.1

Human, Mouse, Rat

HER2 (Phospho-Tyr1248) antibody was raised against a peptide sequence around phosphorylation site of tyrosine1248 (P-E-Y (p) -L-G) derived from Human HER2.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

185 kDa

This antibody detects endogenous level of HER2 only when phosphorylated at tyrosine1248.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

ERBB2

V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

Homo sapiens

Yuan, Lu Qian, Ming Shi, et al. (2008) HER2-dependent MMP-7 expression is mediated by activated STAT3 Guogang Cellular Signalling, 20:1284–1291.

NEU, NGL, HER2, TKR1, CD340, HER-2, MLN19, HER-2/neu, AMPK1, C-erbB-2, ErbB2

WB, IHC, IF

54792098

Liquid