Hercombinatie AMPKβ1

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

AMPKβ1

Q9Y478

Human; Mouse; Rat

Recombinant Human AMPKβ1 protein

5'-AMP-activated protein kinase subunit beta; PRKAB; PRKAB1; AMPK; HAMPKb;5'-AMP-activated protein kinase subunit beta-1;5'-AMP-activated protein kinase subunit beta-1; AMPK; HAMPKb; AMPKβ1

5H6

Unconjugated

IHC

Signal Transduction; Cardiovascular; Cancer; Metabolism

Protein A

0.2 mg/mL

IHC 1:100-1:500

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/t3RGLHwq

IgG, κ