Hercombinatie HIP2 / LIG monoklonaal antilichaam

Huntingtin-interacting protein 2 (HIP2/LIG), is a E2 ubiquitin-conjugating enzyme, which accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, HIP2/LIG catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, while it does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Moreover, HIP2/LIG mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins.

HIP2/LIG

P61086

Human

Recombinant human HIP2/LIG fragment

HIP; UBC; UBE2K; E2-25K; HIP2; HYPG; LIG; UBC1; HIP-2; Huntingtin-Interacting Protein 2; Ubiquitin Carrier Protein; Ubiquitin-Conjugating Enzyme E2 K; Ubiquitin-Conjugating Enzyme E2 (25K) ; Ubiquitin-Conjugating Enzyme E2-25 kDa; Ubiquitin-Conjugating Enzyme E2-25K; Ubiquitin-Protein Ligase

A412

Unconjugated

WB

Neuroscience; Epigenetics and Nuclear Signaling; Cell Biology

Protein A purified

1 mg/mL

WB 1:500-1:2000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/KzqqlNHT

22 kDa

22 kDa

IgG, κ