Hercombinatie NELF-B monoklonaal antilichaam

NELF-B is an essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNApolymerase II. The NELF complex causes transcriptional pausing and is counteracted by the P-TEFb kinase complex. It may be able toinduce chromatin unfolding. NELF-B is a modulator of ligand dependent and independent expression of estrogen receptor-α target genes.NELF-B expression is reduced in metastatic and recurrent breast cancer, suggesting that low levels of NELF-B in breast cancers may serveas an indicator for poor prognosis.

NELF-B

Q8WX92

Human; Mouse

Peptide. This information is proprietary to PTMab.

KIAA; COBRA; NELFB; COBRA1; NELF-B; KIAA1182

A786

Unconjugated

WB; IHC; FCM; IP

Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:10000-1:20000; IHC 1:100; FCM 1:100; IP 1:50-1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/LHUV0RWX

66 kDa

70 kDa

IgG, κ