Hercombinatie PPP1CB monoklonaal antilichaam

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective.

PPP1CB

P62140

Human; Rat; Mouse

Recombinant human PPP1CB fragment

NSLH; PPP1CB; HEL-S-80p; PP-1B; PP1B; PP1beta; PPP1CD; NSLH2; beta isozyme; catalytic subunit; delta isoform; MGC3672; PP 1B; Protein phosphatase 1; Protein phosphatase 1 beta; Protein phosphatase 1 catalytic subunit beta isoform; Protein phosphatase 1 delta; Serine threonine protein phosphatase PP1 beta catalytic subunit; Serine/threonine-protein phosphatase PP1-beta catalytic subunit

A337

Unconjugated

WB; IHC; IF; FCM; IP

Signal Transduction; Cancer; Metabolism; Cell Biology; Epigenetics and Nuclear Signaling

Protein A purified

1 mg/mL

WB 1:500-1:1000; IHC 1:50-1:100; IF 1:200-1:500; FCM 1:50-1:100; IP 1:50-1:100

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/UG7kVVPy

37 kDa

35 kDa

IgG, κ