Hercombinatie WHSC1

WHSC1, also known as MMSET or NSD2, is a SET domain containing histone lysine methyltransferase that can di- and trimethylate histone H3 at lysine 36 (H3K36) . WHSC1 mRNA is highly expressed in embryonic tissues, especially those with high degrees of proliferation, whereas in adult tissues, the mRNA is primarily expressed in thymus and testis. WHSC1 is implicated in cellular adhesion, clonogenic growth and tumorigenicity. Its overexpression has been found in various cancers. It undergoes alternative splicing resulting in different protein isoforms. Recently WHSC1 has been identified as a critical epigenetic regulator for Tfh differentiation.

WHSC1

O96028

Human

Recombinant human WHSC1 fragment

TRX; NSD; WHSC; KIAA; NSD2; KMT3F; KMT3G; MMSET; REIIBP; TRX5; WHS; WHSC1; KIAA1090

A601

Unconjugated

WB

Epigenetics and Nuclear Signaling; Tags & Cell Markers

Protein A purified

1 mg/mL

WB 1:1000-1:5000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/zpd728VQ

153 kDa

153 kDa

IgG, κ