HES5 Antilichaam

HES5 is a member of the HES family of transcriptional repressors, which are the mammalian homologs of the Drosophila Hairy and Enhancer of Split and contain basic Helix-loop-helix (bHLH) and Orange domains (1) . The HES5 gene is a downstream target of the Notch signaling pathway and its expression is downregulated during human cartilage differentiation (2) . HES5 can directly repress transcription of the E3 ligase FBW7-beta, creating a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions (3) .

388585

Q5TA89

NP_001010926

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

HES5 antibody is affinity chromatography purified via peptide column.

Cat. No. 1207 - Raji Cell Lysate

1 mg/mL

HES5 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

HES5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

HES5 antibody is human, mouse and rat reactive. At least two isoforms of HES5 are known to exist; this antibody will detect both isoforms.

HES5

Cat. No. 10-901 - Human Spleen Tissue Slide

Hes family bHLH transcription factor

Homo sapiens

Katoh M and Katoh M. Identification and characterization of human HES2, HES3, and HES5 genes in silico. Int. J. Oncol. 2004; 25:529-34.

Karlsson C, Jonsson M, Asp J, et al. Notch and HES5 are regulated during human cartilage differentiation. Cell Tissue Res. 2007; 327:539-51.

Sancho R, Blake SM, Tendeng C, et al. Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions. PLoS Biol. 2013; 11:e1001586.

Hairy and enhancer of split 5, hes family bHLH transcription factor 5, bHLHb38

ELISA, WB, IHC-P, IF

58219048

Liquid