HET

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant rat IL-2ƒ is a 15.3 kDa protein containing 134 amino acid residues.

RbcL

809853

P17108

NP_446288.1

NM_053836.1

2q25

Rat

Mouse, Rat

MAPTSSPAKE TQQHLEQLLL DLQVLLRGID NYKNLKLPMM LTFKFYLPKQ ATELKHLQCL ENELGALQRV LDLTQSKSFH LEDAGNFISN IRVTVVKLKG SENKFECQFD DEPATVVEFL RRWIAIAQSI ISTM

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

The ED50 as determined by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells is < 0.4 ng/ml, corresponding to a specific activity of > 2.5 x 106 units/mg.

134

Lyophilized

15.3 kDa

E. coli