HET

IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Recombinant rat IL-5 is a 26.0 kDa disulfide-linked homodimeric protein containing two 113 amino acid chains.

Il5; Il-5

24497

Q9R2C9

NP_068606.1

NM_021834.1

10q22

Rat

Human

MEIPMSTVVK ETLIQLSTHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEILFQNL SLIKKYIDGQ KEKCGEERRK TRHFLDYLQE FLGVMSTEWA MEV

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is < 0.5 ng/ml, corresponding to a specific activity of > 2 x 106 units/mg.

113

Lyophilized

26 kDa

E. coli