HET

IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erthroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin’s disease. Recombinant rat IL-9 is a 14.3 kDa protein of 127 amino acid residues including 10 cysteine residues which are fully conserved between the human murine proteins.

Il19

116558

D4A819

NP_001099217

NM_001105747

17p14

Rat

Human

MQRCSTSWGI QHTSYLIENL KDDPSSKCSC SANVTSCLCL PIPSDDCTTP CFQEGMSQVT NATQQSKFSP FFFRVKRIVE TLKSNKCQFF SCEKPCNQTT AGNTVSFLKS LLKTFQKTEV QVQRSRA

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Measured by its ability to enhance MC/9 cell proliferation.

127

Lyophilized

14.3 kDa

E. coli