Hexo Machines 1 Antilichaam

There are four major glucose-phosphorylating isoenzymes, designated Hexokinase 1 I, II, III, and IV (1) . Hexokinase 1 activity is involved in the first step in several metabolic pathways including phosphorylation of glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway (1,2) . Hexokinase 1 2 is the predominant Hexokinase 1 isozyme expressed in insulin-responsive tissues such as skeletal muscle and its expression is insulin-responsive (3) . It is involved in the increased rate of glycolysis seen in rapidly growing cancer cells (4) .

3098

P19367

NP_000179

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

Hexokinase 1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1478 - Rat Bladder Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (94%)

Hexokinase 1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Hexokinase 1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

Hexokinase 1 antibody is human, mouse and rat reactive. Multiple isoforms of Hexokinase 1 are known to exist.

HK1

Hexokinase 1

Homo sapiens

Chen T, Ning D, Sun H, et al. Sequence Analysis and Molecular Characterization of Clonorchis sinensis Hexokinase 1, an Unusual Trimeric 50-kDa Glucose-6-Phosphate-Sensitive Allosteric Enzyme. PLoS One 2014; 9:e107940.

Halestrap AP, Pereira GC, and Pasdois P. The role of Hexokinase 1 in cardioprotection-mechanism and potential for translation. Br. J. Pharmacol. 2014; epub.

Roberts DJ and Miyamoto S. Hexokinase 1 II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy. Cell Death Differ. 2014; epub.

Wang L, Xiong H, Wu F, et al. Hexokinase 1 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth. Cell Rep. 2014; 8:1461-74.

HK, HXK

ELISA, WB, IHC-P, IF

188497754

Liquid