HGF Aanbevolen eiwit

HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α -chain and β -chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α -chain consists of 463 amino acid residues and four kringle domains. The β -chain consists of 234 amino acid residues.

3082

P14210

NP_000592.3

Recombinant Proteins

(BTI-Tn-5B1-4) High-5 Insect cells

Cancer, Cell Cycle, Signal Transduction, Other

Room Temp

The lyophilized HGF recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted HGF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing HGF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Hepatocyte growth factor (hepapoietin A; scatter factor)

Homo sapiens

SF, HGFB, HPTA, F-TCF, DFNB39, Hepatocyte growth factor, Hepatopoietin-A, SF

Human

33859835

Lyophilized